Modification of Bulk Density, Flow Property and Crystallinity of Microcrystalline Cellulose Prepared from Waste Cotton

The most affordable type of tablet is the immediately compressible tablet, which uses microcrystalline cellulose (MCC), a popular pharmaceutical excipient, as filler or binder. To make it compatible with different active drugs and excipients, we tried to change some physical properties MCC. In current study, used chelating agent pretreat waste cotton before pulping, bleaching, finally, hydrochloric acid degradation concentration 2N at 100 °C temperature for 20 min prepare prepared MCC was treated concentrations sodium hydroxide room −20 followed by precipitation ethanol complete washing distilled water till neutralization. Evaluation degree polymerization (DP) FT-IR spectrum confirm identity cellulose. DP found be 216. bulk density unmodified 0.21 while that modified varied from 0.253 0.594. powder showed good flow compared evaluated Hausner index, Carr’s index angle repose. scanning electron microscopy (SEM) revealed rod shape has been changed an oval due treatment °C. X-ray crystallographic (XRD) analysis indicated standard crystallinity (CrI) value 86.82% 87.63%, respectively, ranges 80.18% 60.7% among powder. differences in might variation rearrangement chain particles base temperatures environments. This enabled us drugs.